Tagrix 80 Mg (Osimertinib)

Introduction of Tagrix 80 Mg

Tagrix 80 mg, containing the active ingredient osimertinib, is used for the treatment of metastatic non-small cell lung cancer (NSCLC). Tagrix has been shown to have very good efficacy in targeting specific mutations in the epidermal growth factor receptor (EGFR) gene. Osimertinib has played a significant role in the fight against lung cancer.

Mechanism of action

Tagrix (osimertinib) is considered a third-generation tyrosine kinase inhibitor (TKI) worldwide. EGFR mutations work in an important way by inhibiting activity. In particular, the T790M mutation is associated with resistance to previous generation EGFR-TKIs. It attacks T790M mutations alongside EGFR-sensitive mutations. Tagrix 80 Mg Osimertinib inhibits the growth and spread of cancer cells.

This makes Tagrix suitable for patients with EGFR mutation-positive NSCLC and minimizes off-target effects. Tagrix also crosses the blood-brain barrier, making it effective against brain metastases.

Indications

Tagrix 80 mg is approved for the following indications:

1. For patients with locally advanced or metastatic NSCLC who have an EGFR exon 19 deletion or harbor an exon 21 (L858R) substitution mutation.

2. Patients with T790M-positive NSCLC whose disease has progressed during or after previous EGFR-TKI treatment.

Dosage and Administration of Tagrix

Tagrix dosage is 80 mg taken once daily. It is possible to take Tagrix with or without meals. For best results, patients must adhere to the prescribed regimen. The suggested dosage of Tagrix 80 mg is to be taken as instructed, and the missing dose could be reconstituted.

Pharmacokinetics

Absorption: rapid absorption after oral administration, with peak plasma concentrations achieved within 6 hours.

Distribution: considerable tissue access, encompassing the brain and spine (CNS), and strong protein attachment.

Metabolism: Primarily metabolized by CYP3A4 and CYP3A5 enzymes.

Elimination: Excreted primarily in feces, with a half-life of approximately 48 hours, enabling once-daily dosing.

Clinical Benefits

Improved progression-free survival (PFS): Patients treated with osimertinib have shown prolonged PFS compared to those receiving previous-generation EGFR-TKIs.

Overall survival (OS): Data reflect the long-term benefits of therapy and indicate overall survival rates.

Control of brain metastases: Due to its ability to cross the blood-brain barrier, Tagrix has been shown to be effective in reducing the size and number of brain metastases, providing relief to patients with CNS involvement.

Side effects

Mild to moderate effects: diarrhea, rash, dry skin, and nail toxicity.

Serious adverse events: Rare but significant risks include interstitial lung disease (ILD), cardiomyopathy, and QT interval prolongation.

Warnings

Pregnancy and lactation: Osimertinib may cause fetal harm that may be life-threatening to the fetus. Therefore, use during pregnancy is not recommended. Tagrix 80 mg is not recommended for pregnant women and women of childbearing potential who are not using contraception. Breastfeeding should also be avoided during treatment.

Severe organ dysfunction: Patients with significant renal or hepatic impairment should be monitored closely.

QTc interval prolongation: May cause heart-related complications, including QT interval prolongation and decreased left ventricular ejection fraction.

Drug interactions: Concomitant use with strong CYP3A inducers or inhibitors may alter the efficacy and safety profile of osimertinib.

Conclusion

Tagrix 80 mg (Osimertinib) represents an important advance in the management of EGFR-mutated NSCLC. Its targeted mechanism of action, strong clinical efficacy, and manageable safety profile make it a valuable option for patients. As precision medicine continues to evolve. Tagrix stands as a testament to the potential of targeted therapies to transform cancer care.

How to order IEB Pharma medicine…

WhatsApp: You can send a message by clicking on our WhatsApp button, and a customer service representative of ieb Pharma will assist you in placing your order.

Telegram/Messenger/WeChat: If you want to place an order on our Facebook Messenger, Telegram, or WeChat, then you can easily place an order by clicking on our message option button.

Email: You can message us at [email protected] for details about your order. We answer your call as soon as we can.