Description
Semaglo (semaglutide injection) is a glucagon-like peptide-1 receptor agonist (GLP-1) developed for the treatment of type 2 diabetes in adults and for chronic weight management. It is available in a variety of doses, including 0.25 mg, 0.50 mg, 1.7 mg, 1 mg, and 2.4 mg, allowing for customized treatment based on individual needs. Semaglutide is administered by subcutaneous injection and, when combined with diet and exercise, plays an important role in improving blood sugar control and promoting weight loss.
Mechanism of action
Semaglutide, the active ingredient in Semaglo, mimics the action of the natural GLP-1 hormone. It increases insulin secretion in response to rising blood sugar levels and reduces the release of glucagon, which lowers blood sugar levels. In addition, semaglutide slows gastric emptying, increases satiety, and suppresses appetite. This dual action effectively controls blood glucose levels and supports weight loss.
Indications and uses
Type 2 diabetes
Semaglutide is prescribed to improve glycemic control in adults with type 2 diabetes when diet and exercise alone are insufficient.
It can be used as monotherapy or in combination with other antidiabetic medications such as metformin, SGLT2 inhibitors, or insulin.
Chronic weight management
Indicated for obese (BMI ≥ 30 kg/m²) or overweight (BMI ≥ 27 kg/m²) adults with weight-related comorbidities such as hypertension, dyslipidemia, and type 2 diabetes. It is most effective when combined with a low-calorie diet and increased physical activity.
Dosage and Administration
Starting Dose: 0.25 mg once a week for the first 4 weeks until the body becomes accustomed to the medication.
Titration Dose: Gradually increasing the dose helps minimize gastrointestinal side effects. After 4 weeks, the dose can be increased to 0.50 mg.
Maintenance Dose: Semaglo; depending on individual response, the dose can be further increased to 1 mg, 1.7 mg, or up to 2.4 mg once a week. Administration: Semagro is administered subcutaneously at alternating injection sites in the abdomen, thigh, and upper arm to reduce the risk of lipodystrophy.
Benefits
Effective glycemic control significantly lowers HbA1c levels and reduces the risk of diabetes-related complications.
Weight loss support: clinically proven to promote significant weight loss in obese and overweight individuals.
Cardiovascular protection: Studies suggest a reduced risk of serious cardiovascular events such as heart attack and stroke.
Convenience: Weekly dosing improves compliance compared to daily dosing.
Side effects
Common side effects include:
Nausea
Vomiting
Diarrhea
Constipation
Stomach pain
Decreased appetite
Semaglo side effects:
Pancreatitis
Thyroid C-cell tumors (observed in animal studies; risk to humans unknown)
Hypoglycemia (especially in combination with insulin or sulfonylureas)
Renal impairment
Gallbladder disease
Contraindications and precautions
Not recommended for those with a history of medullary thyroid cancer or multiple endocrine neoplasia type 2.
Caution is advised in patients with a history of pancreatitis or severe gastrointestinal disease.
Do not use in patients with type 1 diabetes or diabetic ketoacidosis.
Conclusion
Semaglo (semaglutide injection) is an innovative treatment for type 2 diabetes and weight management. It allows for effective glycemic control and significant weight loss. Weekly dosing improves ease of use and patient compliance. However, patients should follow their doctor’s instructions to maximize efficacy while minimizing potential side effects. Regular monitoring and adherence to a healthy lifestyle further improve the effectiveness of long-term treatment of the disease.
How to order IEB Pharma medicine…?
Ordering our IEB Pharma medicines is easy. Currently there is no automated ordering system on our website; we offer various options for ordering IEB Pharma medicines.
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