Description
Upadacitinib 15 mg, sold under the brand name Remativ, is an oral Janus kinase (JAK) inhibitor used to treat a variety of inflammatory and autoimmune diseases. It is primarily prescribed for conditions such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), atopic dermatitis, and ulcerative colitis. The 15 mg dose is commonly used for rheumatoid arthritis and psoriatic arthritis, providing effective symptom relief by targeting specific inflammatory pathways.
Pharmacological Classification and Mechanism of Action
Upadacitinib belongs to the class of JAK inhibitors, specifically targeting JAK1. The Janus kinase (JAK) enzyme family plays a key role in cytokine signaling pathways responsible for regulating inflammation and immune responses. By selectively inhibiting JAK1, upadacitinib 15 mg reduces the excessive immune response seen in autoimmune diseases, relieving symptoms such as joint pain, swelling, stiffness, and tissue damage.
Indications and uses
Rematib (upadacitinib 15 mg) is indicated for the treatment of:
Rheumatoid arthritis (RA): For adult patients with moderate to severe active RA who have had an inadequate response to or are intolerant to methotrexate or other disease-modifying antirheumatic drugs (DMARDs).
Psoriatic arthritis (PsA): Effective for patients with active PsA who have not responded adequately to conventional therapies.
Ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA): Approved to reduce inflammation and improve mobility in patients with axial spondyloarthritis.
Atopic dermatitis: Helps treat moderate to severe symptoms by relieving itching, redness, and skin inflammation. Ulcerative colitis and Crohn’s disease: It is effective in treating inflammatory bowel disease by reducing intestinal inflammation and relieving symptoms.
Dosage and Administration
The recommended standard dose of upadacitinib (Rematib) is 15 mg taken orally once daily with or without food. Upadacitinib 15 mg dose adjustments may be necessary in patients with severe renal impairment or in certain clinical situations. In certain cases, such as ulcerative colitis, a higher dose (30 mg daily) may be used initially, and then the dose may be reduced to 15 mg for maintenance therapy.
Contraindications and Precautions
Rematib should not be use in patients with the following conditions:
Active serious infections, such as tuberculosis (TB) or systemic fungal infections. History of hypersensitivity to upadacitinib or its components.
Severe hepatic impairment.
Caution is advise in patients with a history of cancer, cardiovascular disease, thrombosis, or gastrointestinal perforation.
Side effects
Common side effects include:
Upper respiratory tract infections (nasopharyngitis, bronchitis)
Nausea and headache
Elevated liver enzymes
Elevated cholesterol levels
Acne and rash
Serious side effects, although rare, include serious infections, blood clots, cardiovascular disease, and cancer. Regular testing of blood values, liver function, and lipid levels is recommend.
Conclusion
Upadacitinib 15 mg (Rematib) is an effective and targeted treatment option for several autoimmune and inflammatory diseases. Its ability to selectively inhibit JAK1 makes it effective in reducing disease activity while offering a convenient route of oral administration. However, careful monitoring and risk assessment are essential to ensure patient safety and optimize treatment outcomes.
How to order IEB Pharma medicine...?
Ordering our IEB Pharma medicines is easy. Currently there is no automated ordering system on our website; we offer various options for ordering IEB Pharma medicines.
WhatsApp: You can send a message by clicking on our WhatsApp button; a customer service representative of ieb Pharma will assist you in placing your order.
Telegram/Messenger/WeChat: If you want to place an order on our Facebook Messenger or Telegram or WeChat, then you can easily place an order by clicking on our message option button.
Email: You can message us at [email protected] for details about your order. We answer your call as soon as we can.
